γ-生育三烯酚—西宝生物
- 价 格：
面议 /
g
- 供 应 地：上海上海市
- 发布公司：上海西宝生物科技有限公司
- 产品型号：seebio
- 品 牌：seebio
- 发布日期：2016/10/20 10:29:14
- 联系人QQ：1715451510
详细说明
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DeSCRJPTion
Tocotrienols contain an arene ring, a chromanol ring, and an isoprenoid tail; all tocotrienol compounds contain a methyl group on C8 of the arene ring. γ-Tocotrienol contains one additional methyl group on the arene ring, POSTTTIONed ortho to C8. Tocotrienols are members of the vitamin E family, typically isolated from natural sources such as vegetable oils, nuts, and grains. Tocotrienols exhibit strong antioxidative, antiangiogenic, anticancer, and lipid-lowering qualities, although γ-Tocotrienol displays the strongest lipid-lowering activity of all of the tocotrienol compounds. Tocopherols, common substituents of over-the-counter vitamin E supplements, interfere with tocotrienol activity and show weaker antioxidative effects. Tocotrienols exhibit significant radical recycling abilities in cellular models of lipid peroxidation and oxidative damage and suppress HMG-CoA reductase activity. In vitro, these compounds induce apoptosis through inhibition of Id1, EGFR, and NF-κB, and also inhibit vessel formation and proliferation in aortic endothelial cells.
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Specifications
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Cas No.
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14101-61-2
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Product ID
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HT5610
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Product Name
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gamma-Tocotrienol 美国原装进口γ-生育三烯酚 gamma-Tocotrienol
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Synonym
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gamma-Tocotrienol, γ-Tocotrienol
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Formula Wt.
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410.63
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Purity
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>98%
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Store Temp
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-20°C
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References
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Yap WN, Chang PN, Han HY, et al. Gamma-tocotrienol suppresses prostate cancer cell proliferation and invasion through multiple-signalling pathways. Br J Cancer. 2008 Dec 2;99(11):1832-41. PMID: 19002171.
Sen CK, Khanna S, Roy S. Tocotrienols: Vitamin E beyond tocopherols. Life Sci. 2006 Mar 27;78(18):2088-98. PMID: 16458936.
Inokuchi H, Hirokane H, Tsuzuki T, et al. Anti-angiogenic activity of tocotrienol. Biosci Biotechnol Biochem. 2003 Jul;67(7):1623-7. PMID: 12913317.
Parker RA, Pearce BC, Clark RW, et al. Tocotrienols regulate cholesterol production in mammalian cells by post-tranSCRJPTional suppression of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. J Biol Chem. 1993 May 25;268(15):11230-8. PMID: 8388388.
Serbinova E, Kagan V, Han D, et al. Free radical recycling and intramembrane mobility in the antioxidant properties of alpha-tocopherol and alpha-tocotrienol. Free Radic Biol Med. 1991;10(5):263-75. PMID: 1649783.
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西宝生物成立于1999年7月，是一家面向生命科学领域，从事科研机构及生产企业所需的各类试剂、仪器、耗材、书籍等的专业性公司。以生命科学科研及产业为中心，主要从事：1.分子生物学试剂、生化试剂、免疫试剂、生物制品、诊断试剂、药品、食品、精细与专用化学品、医用及实验室耗材、仪器设备等产品的推广应用和进出口服务; 2. 网络服务; 3. 生物技术的开发、转让与咨询服务。
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